Oestrogens, Xenoestrogens and Hormone-Dependent Cancers
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منابع مشابه
Cancer pathogenesis caused by xenoestrogens of environment and food contaminants: A Review
The environmental and food contaminants, including therapeutic agents (e.g, antibiotics, antihypertensive drugs, etc.) and oestrogenic endocrine disruptors (xenoestrogens or xenobiotic chemicals), which mediate the oestrogens may lead to the development of cancer. Oestrogens and their metabolites are involved in the cancer pathogenesis of breast, uterus, ovary, pituitary gland, testicle, liver,...
متن کاملSeveral environmental oestrogens are also anti-androgens.
There is presently considerable interest in endocrine disruption which is a new area of endocrinology concerned with chemicals that mimic hormones, in particular sex steroids. It has been hypothesised that exposure to such chemicals may be responsible for adverse effects in both humans and wildlife. Until now, chemicals that mimic oestrogens (so-called xenoestrogens) have been the main focus of...
متن کاملEnvironmental oestrogens and breast cancer: evidence for combined involvement of dietary, household and cosmetic xenoestrogens.
UNLABELLED Many environmental compounds with oestrogenic activity are measurable in the human breast and oestrogen is a known factor in breast cancer development. Exposure to environmental oestrogens occurs through diet, household products and cosmetics, but concentrations of single compounds in breast tissue are generally lower than needed for assayable oestrogenic responses. Results presented...
متن کاملCellular and biochemical mechanisms by which environmental oestrogens influence reproductive function.
The biology and physiology of the male as well as female reproductive system is hormonally regulated. Abnormalities in the dynamics of hormone production, metabolism and elimination, as well as their binding to certain target tissues, has been associated with pathophysiological conditions of the reproductive system. Although oestrogens are known to be one of the major hormone groups in regulati...
متن کاملEnvironmental Xenoestrogens Super-Activate a Variant Murine ER Beta in Cholangiocytes
High systemic levels of oestrogens are cholestatic and primary biliary cholangitis (PBC)-which is characterized by hepatic ductular inflammation-is thought to be triggered by exposure to xenobiotics such as those around landfill sites. Xenoestrogens may be a component of this chemical trigger. We therefore hypothesized that xenoestrogens are present at higher levels in the proximity of landfill...
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تاریخ انتشار 2017